The Khorasan Razavi Province Red Crescent Society has adopted various strategies with the aim of achieving better performance from its employees. These strategies include flexibility, timely response during crises, organizational resilience, and an adaptable culture. The purpose of this study is to investigate the effect of transformational leadership on organizational resilience with the mediating role of adaptive culture in the Red Crescent Society of Khorasan Razavi Province. This research has an applied purpose and was conducted using a descriptive and survey method. The data collection tool in the present study was a standard questionnaire including the variables of transformational leadership, organizational resilience, and adaptive culture based on the study of Maddy (2023: 440-468). To measure reliability, Cronbach's alpha coefficient was obtained for the variables of transformational leadership (0.81), organizational resilience (0.86), and adaptive culture (0.86).The statistical population of this study included employees and volunteers in the Red Crescent Society of the cities of Khorasan Razavi Province, which, based on the Morgan table, had a sample size of 460 people based on a non-random method available, of which 130 employees and volunteers were selected. To assess the validity of the variables, after approval by professors and experts, convergent and divergent validity and confirmatory factor analysis were conducted. Composite reliability was also confirmed. The findings were analyzed using descriptive and inferential statistics using SPSS and PLS Smart software.The results showed that transformational leadership, in addition to its direct effect on adaptive culture, also indirectly affects organizational resilience through adaptive culture, and the direct effect of adaptive culture on organizational resilience was confirmed.